Melanotan I 10mg

Afamelanotide (NDP-α-MSH)

CAS: 75921-69-6

2019

FDA approval year

Scenesse (Clinuvel)

EPP

Approved indication

Erythropoietic protoporphyria

Receptor Targets

MC1R (preferred)Melanogenesis, photoprotection

MC3R/MC4R (weaker)Lower off-target activation vs MT-II

$53.99In Stock

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Technical Data & References

Chemistry, identifiers, and primary literature for Melanotan I (Afamelanotide / NDP-α-MSH) — available as lyophilized powder on Clav Tides.

Short Sequence: Ac-SYS-Nle-EHfRWGKPV-NH2 (D-Phe at position 7)
Full Sequence: Acetyl-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2
Salt Form: Acetate
# Amino Acids: 13
Purity: ≥98%
Molecular Formula: C78H111N21O19
Molecular Weight: 1646.89 g/mol
CAS Number: 75921-69-6
PubChem CID: 16154873
Source: Synthetic (linear α-MSH super-agonist)
Appearance: Lyophilized powder
Availability: Lyophilized powder — Clav Tides

Primary Literature

1.
Sawyer TK, Sanfilippo PJ, Hruby VJ, et al. 4-Norleucine, 7-D-phenylalanine-α-melanocyte-stimulating hormone: a highly potent α-melanotropin with ultralong biological activity. Proc Natl Acad Sci U S A. 1980 Oct;77(10):5754-8.
DOI: 10.1073/pnas.77.10.5754 PMID: 6255465 PMC350153
2.
Langendonk JG, Balwani M, Anderson KE, et al. Afamelanotide for Erythropoietic Protoporphyria. N Engl J Med. 2015 Jul 2;373(1):48-59.
DOI: 10.1056/NEJMoa1411481 PMID: 26132941

Research use only. Data compiled from published literature and regulatory registries. Melanotan I 10mg is supplied for in-vitro laboratory research — not for human consumption, injection, or therapeutic use.

Approved

FDA approved (2019) as Scenesse for EPP

Afamelanotide (Scenesse) approved for erythropoietic protoporphyria. No approval for cosmetic pigmentation — research use only outside approved indication.

Also Known As

AfamelanotideNDP-α-MSH[Nle4, D-Phe7]-α-MSHScenesse (clinical form)Melanotan IMT-I

Reconstitution & Dosing Guide

BAC Water

2mL

Final Concentration

5 mg/mL

Per Dose

0.5 mg = 0.1 mL · 1 mg = 0.2 mL

Start with minimum effective dose; sensitivity varies with skin type

Often Stacked With

Melanotan II

Cyclic MC receptor broad agonist — alternative research comparator

View compound →

Published References

1.
Langendonk JG, Balwani M, Anderson KE, et al.. Afamelanotide for Erythropoietic Protoporphyria. NEJM (2015) PMID: 26132941

Research Use Only. This product is intended for in-vitro laboratory research only. Not for human consumption, injection, or therapeutic use. Not medical advice. Always consult applicable regulations in your jurisdiction.

Price Comparison

Supplier	Purity	Price	Shipping
our verified supplier	>98% HPLC	$53.99	Free over $200
Generic Research Suppliers	Varies (often <95%)	Similar–Higher	Varies
Pharmaceutical (Rx only)	Pharmaceutical grade	Not available for research	Rx required