Research Specifications
- Sequence:
- Lys-Gln-Glu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr (PE 22-28, 13 aa)
- Parent:
- Spadin (17-aa fragment of sortilin propeptide)
- Molecular weight:
- ~1700 Da
- Vial:
- 10mg lyophilized
- Purity:
- ≥98% HPLC verified
PE-22-28 10mg
Spadin 17-amino-acid sortilin propeptide fragment
CAS: 1404-08-3
Days
Antidepressant onset
Mazella 2010
TREK-1
Selective target
Heurteaux 2006
Spadin 22-28
Fragment origin
Sortilin cleavage
Receptor Targets
TREK-1 (KCNK2)Background K+ channel blockade → neuronal depolarization
$71.99In Stock
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Preclinical
Preclinical novel antidepressant research
No human clinical trials. Active preclinical research tool for TREK-1 biology and rapid-onset antidepressant mechanisms.
Also Known As
PE-22-28Spadin(22-28)TREK-1 blocker peptideSortilin-derived antidepressant fragment
Reconstitution & Dosing Guide
BAC Water
2mL
Final Concentration
5 mg/mL
Per Dose
100 μg = 0.02 mL (2 IU)
Rodent-protocol-derived dosing; human-research-equivalent exploratory
Often Stacked With
Published References
- 1.Mazella J, Pétrault O, Lucas G, et al.. Spadin, a sortilin-derived peptide, targeting rodent TREK-1 channels: a new concept in the antidepressant drug design. PLoS Biology (2010) PMID: 20859533
- 2.Heurteaux C, Lucas G, Guy N, et al.. Deletion of the background potassium channel TREK-1 results in a depression-resistant phenotype. Nature Neuroscience (2006) PMID: 17086178
Research Use Only. This product is intended for in-vitro laboratory research only. Not for human consumption, injection, or therapeutic use. Not medical advice. Always consult applicable regulations in your jurisdiction.
Price Comparison
| Supplier | Purity | Price | Shipping |
|---|---|---|---|
| our verified supplier | >98% HPLC | $71.99 | Free over $200 |
| Generic Research Suppliers | Varies (often <95%) | Similar–Higher | Varies |
| Pharmaceutical (Rx only) | Pharmaceutical grade | Not available for research | Rx required |
Buy Peptides Compounds
PE-22-28 10mg
$71.99