Part of Clavicular's Looksmaxxing Stack
Retatrutide 20mg
Triple GLP-1/GIP/Glucagon receptor agonist
CAS: 2381089-83-2
Featured in Clavicular's looksmaxxing protocol
−24.2%
Mean Weight Reduction
Phase 2, 12mg dose (NEJM 2023)
3 receptors
Simultaneous Targets
GLP-1 / GIP / Glucagon
Receptor Targets
Technical Data & References
Chemistry, identifiers, and primary literature for Retatrutide — available as lyophilized powder on Clav Tides.
- Short Sequence
- Y-{Aib}-QGTFTSDYSI-{α-Me-Leu}-LDK-{Lys(AEEA-γGlu-C20 diacid)}AQ-{Aib}-AFIEYLLEGGPSSGAPPPS-NH2
- Full Sequence
- Tyr-{Aib}-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Ile-{α-Me-Leu}-Leu-Asp-Lys-{diacid-C20-gamma-Glu-(AEEA)-Lys}-Ala-Gln-{Aib}-Ala-Phe-Ile-Glu-Tyr-Leu-Leu-Glu-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2
- Salt Form
- Sodium salt
- # Amino Acids
- 39
- Purity
- 99.37%
- Molecular Formula
- C221H342N46O68
- Molecular Weight
- 4731.33 g/mol
- CAS Number
- 2381089-83-2
- PubChem CID
- 485663353
- Source
- Synthetic
- Appearance
- Lyophilized powder
- Availability
- Lyophilized powder — Clav Tides
Primary Literature
- 1.
Coskun T, Urva S, Roell WC, et al. LY3437943, a novel triple glucagon, GIP, and GLP-1 receptor agonist for glycemic control and weight loss: From discovery to clinical proof of concept. Cell Metab. 2022 Sep 6;34(9):1234-1247.e9.
- 2.
Jastreboff AM, Kaplan LM, Frías JP, et al. Triple-Hormone-Receptor Agonist Retatrutide for Obesity — A Phase 2 Trial. N Engl J Med. 2023 Aug 10;389(6):514-526.
- 3.
Sanyal AJ, Kaplan LM, Frías JP, et al. Triple hormone receptor agonist retatrutide for metabolic dysfunction-associated steatotic liver disease: a randomized phase 2a trial. Nat Med. 2024 Jul;30(7):2037-2048.
- 4.
Ma J, et al. Comparison of the effects of Liraglutide, Tirzepatide, and Retatrutide on diabetic kidney disease in db/db mice. Endocrine. 2024 Aug 30.
- 5.
Ullah MI, Tamanna S. Obesity: Clinical Impact, Pathophysiology, Complications, and Modern Innovations in Therapeutic Strategies. Medicines (Basel). 2025 Jul 28;12(3):19.
Research use only. Data compiled from published literature and regulatory registries. Retatrutide 20mg is supplied for in-vitro laboratory research — not for human consumption, injection, or therapeutic use.
Research Use Only. This product is intended for in-vitro laboratory research only. Not for human consumption, injection, or therapeutic use. Not medical advice. Always consult applicable regulations in your jurisdiction.
Price Comparison
| Supplier | Purity | Price | Shipping |
|---|---|---|---|
| our verified supplier | >98% HPLC | $224.99 | Free over $200 |
| Generic Research Suppliers | Varies (often <95%) | Similar–Higher | Varies |
| Pharmaceutical (Rx only) | Pharmaceutical grade | Not available for research | Rx required |
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