Part of Clavicular's Looksmaxxing Stack

TB-500 complements BPC-157 in the looksmaxxing recovery stack. Often recommended alongside Clavicular's core protocol for enhanced healing.

Clav's Pick

Research Specifications

Active Sequence:: Ac-LKKTETQ (core actin-binding motif)
Full Name:: Thymosin Beta-4 fragment (synthetic analogue)
Molecular Weight:: 2174.5 Da
Form:: Lyophilized powder
Purity:: ≥98% (HPLC verified)
Storage:: −20°C long-term / 4°C up to 4 weeks reconstituted
Reconstitution:: Bacteriostatic water

TB-500 (Thymosin Beta-4) 10mg

Thymosin Beta-4 fragment (Ac-LKKTETQ active region)

CAS: 77591-33-4

Synthetic thymosin beta-4 fragment. Researched for actin dynamics, satellite cell activation, and systemic tissue repair.

Featured in Clavicular's looksmaxxing protocol

Amino Acids (Tβ4)

Full native peptide

2174 Da

Molecular Weight

NCBI PubChem

Ubiquitous

Natural Distribution

Found in all nucleated cells

$59.99In Stock

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≥98% Purity Verified Free Shipping $200+ HPLC Tested

Why Clavicular Uses This Peptide

TB-500 complements BPC-157 in the looksmaxxing recovery stack. Often recommended alongside Clavicular's core protocol for enhanced healing.

See Clavicular's complete looksmaxxing stack →

Actin Sequestration & Satellite Cell Activation

TB-500 is a synthetic analogue of the active region of Thymosin Beta-4 (Tβ4), a naturally occurring 43-amino-acid peptide found in nearly all human and animal cells. Its primary mechanism is G-actin sequestration via the Ac-LKKTETQ motif — this prevents actin polymerization in a way that promotes cell migration, tissue repair, and angiogenesis. TB-500 also activates satellite cells (muscle stem cells), upregulates metalloproteinases for ECM remodeling, and has anti-inflammatory properties.

Research Highlights

Muscle Repair & Satellite Cell Activation

Tβ4 and its analogues have been shown to promote satellite cell differentiation in in vitro and animal models, supporting skeletal muscle regeneration after injury. This makes TB-500 relevant to research involving caloric restriction or training-induced muscle damage.

Cardiac & Vascular Research

Multiple studies have examined Thymosin Beta-4's effects on cardiac repair post-infarction, demonstrating reduced cardiomyocyte apoptosis and improved neovascularization in mouse models. TB-500's angiogenic properties derive from its upregulation of VEGF and other pro-angiogenic factors.

Anti-inflammatory Properties

TB-500 reduces levels of pro-inflammatory cytokines including TNF-α and IL-1β in animal inflammation models. This anti-inflammatory action complements its tissue repair effects, particularly in chronic injury research contexts.

Research FAQ

What is the difference between TB-500 and BPC-157?

TB-500 (Thymosin Beta-4 fragment) primarily acts via actin sequestration and satellite cell activation — making it particularly relevant to muscle and connective tissue repair research. BPC-157 acts via VEGFR2, FAK-paxillin, and nitric oxide pathways with a broader tissue profile including GI cytoprotection. They are complementary rather than redundant.

Why is TB-500 in Clavicular's recovery stack?

During aggressive caloric restriction protocols studied alongside GLP-1 agonists, preserving lean mass is a research priority. TB-500's satellite cell activation and anti-catabolic properties in animal models provide a mechanistic rationale for its inclusion alongside BPC-157 in recovery-focused research stacks.

How is TB-500 different from native Thymosin Beta-4?

TB-500 is a synthetic fragment corresponding to the Ac-LKKTETQ core actin-binding region of the 43-amino-acid Thymosin Beta-4 peptide. It retains the primary biological activity of the parent peptide at a lower molecular weight and cost, with comparable results in published research.

Research Use Only. This product is intended for in-vitro laboratory research only. Not for human consumption, injection, or therapeutic use. Not medical advice. Always consult applicable regulations in your jurisdiction.

Research Guides

BPC-157 vs TB-500: Complete Comparison Peptides for Body Recomposition: TB-500's Role Clavicular's Full Stack Protocol

Price Comparison

Supplier	Purity	Price	Shipping
Apollo (via ClavTides)	>98% HPLC	$59.99	Free over $200
Generic Research Suppliers	Varies (often <95%)	Similar–Higher	Varies
Pharmaceutical (Rx only)	Pharmaceutical grade	Not available for research	Rx required