Back to Products
CJC1295/Ipamorelin (No DAC)

Research Specifications

Components:
CJC-1295 No DAC (Mod GRF 1-29) + Ipamorelin
CJC-1295 MW:
3367.9 Da
Ipamorelin MW:
711.9 Da
Form:
Lyophilized powder blend
Purity:
≥98% each component (HPLC verified)
Storage:
−20°C long-term / 4°C up to 4 weeks reconstituted
Reconstitution:
Bacteriostatic water

CJC1295/Ipamorelin (No DAC)

Pre-blended GHRH + ghrelin receptor agonist combination. Synergistic growth hormone secretagogue stack — amplified GH pulse without DAC-mediated blunting.

~10×

GH Pulse Amplification

vs either compound alone

~30 min

CJC No DAC Half-life

Preserves pulsatile GH pattern

Selective

Ipamorelin Specificity

No cortisol or prolactin elevation

Receptor Targets

GHRH-R↑ GH synthesis & release from pituitary somatotrophs (CJC-1295)
GHSR-1a↑ GH pulse amplitude, selective — no cortisol/prolactin (Ipamorelin)
$50.00In Stock
Buy Now
≥98% Purity Verified Free Shipping $200+ HPLC Tested

GHRH + Ghrelin Receptor Dual Pathway GH Secretion

This blend combines CJC-1295 No DAC (a GHRH analogue, also known as Mod GRF 1-29) with Ipamorelin (a selective ghrelin receptor agonist / GHSR-1a agonist). CJC-1295 No DAC binds GHRH receptors on pituitary somatotrophs, stimulating GH synthesis and secretion with a short half-life (~30 min) that preserves the pulsatile GH release pattern. Ipamorelin selectively activates GHSR-1a, amplifying GH pulse magnitude synergistically with GHRH signaling. Unlike GHRP-6 and GHRP-2, Ipamorelin does not stimulate cortisol or prolactin release at research doses, making it the cleanest ghrelin agonist. The combination produces approximately 10× greater GH pulse amplitude than either compound alone.

Research Highlights

Synergistic GH Pulse Amplification

GHRH (via CJC-1295) and ghrelin receptor agonists (via Ipamorelin) act through independent intracellular signaling pathways — Gs/cAMP (GHRH) and Gq/IP3 (ghrelin). Co-stimulation of both pathways in pituitary somatotrophs is synergistic: combined GH release significantly exceeds the additive sum of either alone, which is the pharmacological rationale for the pre-blended formulation.

No DAC Formulation Advantage

CJC-1295 with DAC (Drug Affinity Complex) extends half-life to ~8 days via albumin binding, creating a sustained GH elevation rather than discrete pulses. The No DAC formulation preserves physiological pulsatility — brief, high-amplitude GH pulses — which is the natural growth hormone secretion pattern and may be important for IGF-1 signaling patterns in research.

Body Recomposition Research Context

GH secretagogue research intersects with GLP-1 agonist protocols in body recomposition studies. While GLP-1 agonists reduce fat mass, GH pulses amplified by CJC/Ipa stimulate IGF-1 production, supporting lean mass preservation and anabolic signaling. This mechanistic complementarity is the basis for their co-use in looksmaxxing research protocols.

Research FAQ

What is the difference between CJC-1295 No DAC and CJC-1295 with DAC?
CJC-1295 No DAC (Mod GRF 1-29) has a ~30-minute half-life and produces discrete GH pulses when dosed. CJC-1295 with DAC has a Drug Affinity Complex modification enabling albumin binding, extending half-life to ~8 days for sustained GH elevation. The No DAC version better preserves physiological GH pulsatility, which is why it is the standard for GH secretagogue research stacks.
Why combine CJC-1295 with Ipamorelin rather than using either alone?
GHRH (CJC-1295) and ghrelin receptor agonists (Ipamorelin) activate two independent intracellular pathways — Gs/cAMP and Gq/IP3 respectively. This dual stimulation of pituitary somatotrophs produces ~10× the GH pulse amplitude of either alone. The blend exploits this synergy in a single reconstituted preparation.
Does Ipamorelin elevate cortisol?
Unlike GHRP-6 and GHRP-2, Ipamorelin is highly selective for GHSR-1a and does not significantly elevate ACTH or cortisol at research doses. This selectivity makes it the preferred ghrelin receptor agonist for GH secretagogue research where minimising cortisol confounds is important.
How does the CJC/Ipa blend relate to Clavicular's protocol?
Clavicular's looksmaxxing stack focuses on retatrutide for fat loss and aesthetic recomposition. CJC-1295/Ipamorelin is included in some extended protocols as a GH pulse amplifier — the GH/IGF-1 axis supports lean mass preservation during aggressive caloric restriction, complementing retatrutide's fat-preferential weight loss profile.

Research Use Only. This product is intended for in-vitro laboratory research only. Not for human consumption, injection, or therapeutic use. Not medical advice. Always consult applicable regulations in your jurisdiction.

Price Comparison

SupplierPurityPriceShipping
Apollo (via ClavTides)>98% HPLC$50.00Free over $200
Generic Research SuppliersVaries (often <95%)Similar–HigherVaries
Pharmaceutical (Rx only)Pharmaceutical gradeNot available for researchRx required

CJC1295/Ipamorelin (No DAC)

$50.00

Buy Now