Research Specifications
- Sequence:
- Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2 (Ac-EEMQRRADE-NH2)
- INCI Name:
- Acetyl Glutamyl Heptapeptide-3
- Molecular Weight:
- 1075.2 Da
- Form:
- Lyophilized powder
- Purity:
- ≥98% (HPLC verified)
- Storage:
- −20°C long-term / 4°C up to 4 weeks
- Solubility:
- Water-soluble; stable in physiological pH range
SNAP-8 10mg
Acetyl Octapeptide-3 (SNARE complex inhibitor)
CAS: 868844-74-0
Octapeptide SNAP-8 (Acetyl Glutamyl Heptapeptide-3). Researched as a topical anti-wrinkle compound that inhibits SNARE complex formation to reduce facial muscle contraction depth.
49%
Wrinkle Depth Reduction
In vitro fibroblast study
8
Amino Acids
Octapeptide
1075 Da
Molecular Weight
Ac-EEMQRRADE-NH2
SNARE Complex Inhibition & Myosin Light Chain Modulation
SNAP-8 is a synthetic octapeptide (Ac-EEMQRRADE-NH2) that mimics the N-terminal region of SNAP-25, a protein involved in the SNARE complex that mediates acetylcholine vesicle release at neuromuscular junctions. By competing with SNAP-25 for SNARE complex incorporation, SNAP-8 reduces catecholamine release at the NMJ, attenuating muscle contraction intensity. Research suggests this mechanism reduces the depth of expression lines (glabellar lines, crow's feet) without full paralysis. It also modulates myosin light chain phosphorylation, contributing to reduced muscle fiber tension.
Research Highlights
SNARE Complex Research
The SNARE hypothesis for SNAP-8 activity posits competitive inhibition of SNAP-25 in the SNARE complex (SNAP-25 + Syntaxin-1 + VAMP). In vitro neuronal culture studies show reduced catecholamine secretion with SNAP-8, consistent with the proposed mechanism. This makes it relevant to NMJ signaling research beyond cosmetic applications.
Facial Muscle Contraction Studies
Clinical studies in cosmetic research using 10% SNAP-8 formulations showed measurable reduction in forehead wrinkle depth as assessed by optical profilometry — with effects appearing after 4-28 days of twice-daily topical application. The magnitude is lower than botulinum toxin but significant vs untreated controls.
Looksmaxxing Protocol Context
In looksmaxxing research contexts, SNAP-8 is used as a topical skin quality compound alongside systemic peptides like GHK-Cu and TB-500. The combination targets both structural skin matrix (GHK-Cu → collagen) and neuromuscular wrinkle depth (SNAP-8 → SNARE inhibition) for a comprehensive aesthetic research protocol.
Research FAQ
How does SNAP-8 differ from botulinum toxin mechanistically?
Why is SNAP-8 in Clavicular's aesthetic stack?
What is the research concentration for SNAP-8?
Research Use Only. This product is intended for in-vitro laboratory research only. Not for human consumption, injection, or therapeutic use. Not medical advice. Always consult applicable regulations in your jurisdiction.
Price Comparison
| Supplier | Purity | Price | Shipping |
|---|---|---|---|
| Apollo (via ClavTides) | >98% HPLC | $45.00 | Free over $200 |
| Generic Research Suppliers | Varies (often <95%) | Similar–Higher | Varies |
| Pharmaceutical (Rx only) | Pharmaceutical grade | Not available for research | Rx required |
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SNAP-8 10mg
$45.00