Research Specifications
- Design:
- p53(12-26) + membrane resident sequence from HDM-2
- Length:
- 32 amino acids
- Molecular weight:
- ~3600 Da
- Vial:
- 30mg lyophilized
- Purity:
- ≥98% HPLC verified
PNC-27 30mg
p53 mimetic anticancer peptide
CAS: 325973-77-3
Necrosis
Kill mechanism
Sarafraz-Yazdi 2010
HDM-2
Surface target
Cancer cell marker
32 aa
Length
p53 + MRS chimera
Preclinical anticancer research
Active preclinical research at NYU and collaborators. No human clinical trials. Translation slowed by peptide manufacturing and pharmaceutical development challenges.
Also Known As
Reconstitution & Dosing Guide
BAC Water
3mL
Final Concentration
10 mg/mL
Per Dose
Research doses vary widely; protocols mostly preclinical
Moderately hydrophobic — gentle mixing, allow full dissolution
Published References
- 1.Sarafraz-Yazdi E, Bowne WB, Adler V, et al.. Anticancer peptide PNC-27 adopts an HDM-2-binding conformation and kills cancer cells by binding to HDM-2 on their membranes. Proc Natl Acad Sci USA (2010) PMID: 20133699
Research Use Only. This product is intended for in-vitro laboratory research only. Not for human consumption, injection, or therapeutic use. Not medical advice. Always consult applicable regulations in your jurisdiction.
Price Comparison
| Supplier | Purity | Price | Shipping |
|---|---|---|---|
| our verified supplier | >98% HPLC | $107.99 | Free over $200 |
| Generic Research Suppliers | Varies (often <95%) | Similar–Higher | Varies |
| Pharmaceutical (Rx only) | Pharmaceutical grade | Not available for research | Rx required |
Buy Peptides Compounds
PNC-27 30mg
$107.99