Research Specifications
- Sequence:
- H-Ala-Glu-Asp-Gly-OH (Epithalon / Epitalon)
- CAS Number:
- 307297-39-8
- Molecular Weight:
- 482.46 Da
- Form:
- Lyophilized powder
- Purity:
- ≥98% (HPLC verified)
- Storage:
- −20°C long-term / 4°C up to 4 weeks reconstituted
- Reconstitution:
- Bacteriostatic water or sterile saline
Epithalon 50mg
Tetrapeptide Ala-Glu-Asp-Gly — Khavinson's pineal bioregulator. Researched for telomerase activation, telomere elongation, and circadian rhythm restoration.
33%
Telomere Length Increase
Khavinson et al., in vitro
40+
Published Studies
Khavinson lab, St. Petersburg
482 Da
Molecular Weight
Tetrapeptide Ala-Glu-Asp-Gly
Telomerase Activation & Pineal Bioregulation
Epithalon (Epitalon, tetrapeptide Ala-Glu-Asp-Gly) is a synthetic version of the natural peptide Epithalamin, isolated from bovine pineal gland extracts by Vladimir Khavinson. Its primary researched mechanism involves activation of telomerase (hTERT) — the enzyme that extends telomere length. Critically, telomerase is active in germline and stem cells but silenced in most somatic cells; Epithalon appears to reactivate hTERT expression in fibroblasts and lymphocytes in vitro. It also regulates melatonin synthesis in the pineal gland, suppresses luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in aged animal models, and exhibits antioxidant properties via free radical scavenging.
Research Highlights
Telomerase Activation (Khavinson Research)
Khavinson et al. published in vitro studies showing Epithalon at nanomolar concentrations activates hTERT expression in human fetal fibroblasts, producing measurable telomere elongation (24-33%). The mechanism appears to involve epigenetic chromatin remodeling rather than direct enzyme activation — with histone H3/H4 acetylation at the hTERT promoter proposed as the pathway.
Pineal Gland & Melatonin Regulation
Animal studies show Epithalon normalises the age-related decline in pineal melatonin synthesis. In aged rodents, the compound restored nightly melatonin surges to levels observed in young adults, with associated improvements in sleep architecture and circadian rhythm markers. This neuroendocrine action distinguishes Epithalon from purely systemic peptides.
Longevity Research in Rodents
Multiple rodent studies from Khavinson's lab reported 10-16% lifespan extension in treated groups vs controls, alongside reduced incidence of spontaneous tumors. While the mechanistic link to telomerase activation is compelling, the animal data require independent replication and human translation studies remain limited.
Research FAQ
What is Epithalon and how is it different from other anti-aging peptides?
Is the telomerase activation research well-established?
Why is Epithalon included in looksmaxxing protocols?
What reconstitution volume is used for Epithalon 50mg?
Research Use Only. This product is intended for in-vitro laboratory research only. Not for human consumption, injection, or therapeutic use. Not medical advice. Always consult applicable regulations in your jurisdiction.
Price Comparison
| Supplier | Purity | Price | Shipping |
|---|---|---|---|
| Apollo (via ClavTides) | >98% HPLC | $139.99 | Free over $200 |
| Generic Research Suppliers | Varies (often <95%) | Similar–Higher | Varies |
| Pharmaceutical (Rx only) | Pharmaceutical grade | Not available for research | Rx required |
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